| 학회 | 한국재료학회 |
| 학술대회 | 2016년 가을 (11/16 ~ 11/18, 경주 현대호텔) |
| 권호 | 22권 2호 |
| 발표분야 | B. 나노화학/바이오 재료 분과 |
| 제목 | Facile synthesis of monodisperse porous silicon nanoparticles for well-designed theranostics |
| 초록 | Nanomedicine offers great opportunities to treat incurable diseases including various cancers and neurodegenerative diseases due to unique characteristics of nanomaterials such as silica nanoparticles, gold nanomaterials with various shapes, and magnetic nanoparticles. Interdisciplinary nanomedicine field has been attracted a lot of attentions because nanomaterials enable non-invasive multi-modal imaging, targeting disease site for minimizing side effect of drugs to normal tissues, and effective loading and intracellular translocation of drugs. Thereby, nanomedicine provides great potentials to solve a lot of difficulties existing in conventional therapy. However, there are several requirements for nanomedicine to move forward in clinically relevant technology including biocompatibility, well-established synthetic procedure in monodisperse and reproducible way, facile surface modification for introduction of drug and targeting moiety, superior therapeutic efficacy, and finally proper biodegradability for elimination of materials from body. To fulfill these requirements, a lot of efforts have been invested in synthesis and surface modification of various nanomaterials in various fields. Among various nanomaterials, porous materials provides advantages in high drug loading capacity reducing the dosage of drug delivery vehicle and protection of drugs from being exposed to degradable environment. With these regards, it is required the synthesis of biocompatible nanomaterials possessing porous structure and easily modifiable surface. Here we present a synthesis of porous silicon nanoparticles for application in drug delivery for effective treatment of cancer. Through efficient reduction of silica nanoparticle, we could synthesize monodisperse porous silicon nanoparticle and also show potentials as effective cancer therapeutics without considerable toxicity. |
| 저자 | 나희경, 이태걸 |
| 소속 | KRISS |
| 키워드 | <P>nanomedicine; theranostics; silicon nanoparticle</P> |
