| 초록 |
Multifunctional polymeric drug carriers for optometrical uses have been intensively studied for the last decades, as it readily allows for a stimuli-responsive or sustained release of pharmaceutical agents. Herein, we describe fabrication of a micro-sized pH-responsive drug carrier, morphological, kinetic analysis, and consistency assessment. The microgel was prepared by copolymerizing N-isopropylacrylamide with methacrylic acid. Time-based release experiments were performed in a pH range reflected physiological conditions of dry and normal eyes (pH 6.9 - 7.9) We tagged the hyaluronic acids with a fluorescent dye to better trace the drug molecules and to obtain reliable kinetic data in a pH range of physiological conditions. As a result, the release amounts at basic condition significantly increased. Comprehensively, this complex can markedly enhance pharmaceutical effects during a long-term medication for dry eye syndrome. |
