| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Macromolecular RNA target sensor by exploiting conformational changes in suprmolecular nanostructures |
| 초록 |
The detection of biological analytes by fluorescent biosnsors has been a topic of considerable research interest. We study about a ratiometric fluorescence biosensor based on self-assembled peptide nanostructures (SPN), which can respond to conformational changes induced by RNA ligand binding. The design of the SPN biosensor was inspired by the conformational stabilization and multimerization behaviors of the HIV-1 Rev protein induced by cooperative protein-protein and protein-RNA interactions. Because conformation-sensitive SPN biosensors can orchestrate binding and signal transduction events, they can be developed as highly sophisticated and smart nanomaterials for biosensing. |
| 저자 |
김희원, 임용범
|
| 소속 |
연세대 |
| 키워드 |
peptide; RNA sensor; HIV-1
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| E-Mail |
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