| 초록 |
Natural products are the richest source of chemical compounds for drug discovery. Particularly, bacterial secondary metabolites are a structurally diverse and biologically valuable group of small molecules, and have been contributed as an important source for drug leads. Genome mining driven by advances in genome sequencing and mining, bioinformatics, as well as advances in experimental techniques for the potential of biosynthetic pathway manipulation to awake silent (cryptic) gene clusters under laboratory cultivation, have accelerated the discovery process for new natural products very efficiently. As we are interested in the discovery of new bacterial secondary metabolites based on these advanced genome mining skills, Streptomyces rapamycinicus NRRL5491 has been genetically investigated and analyzed as to have many biosynthetic gene clusters (BGCs) encoding secondary metabolites. |
