| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
ATP-Independent Intracellular Gene Delivery Mediated by Polyplex conjugated with amphiphilic Bile Acid |
| 초록 |
Nanoscale molecular amphiphilic polymer conjugates, bile acid-polyethylenimine (BA-PEI), present efficient gene transfer route into mammalian cells across the cell membrane. This process doesn’t need the aid of endocytosis or other ATP-dependent processes, thus mimicking cell-penetrating peptides. The exposure of a hydrophilic face of the amphiphilic BA moiety on the surface of BA-PEI/DNA complex that mediates direct contact of the BA molecules to the cell surface seems to play an important role in the endocytosis- and energy-independent internalization process. The new modality of the polymeric biomimetics can be applied to enhanced delivery of macromolecular therapeutics. |
| 저자 |
김동민, 정재백, 임수연, 김다훤, 조희주, 정지훈
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| 소속 |
성균관대 |
| 키워드 |
Nonviral gene delivery; Polyplex; Nano; systemic delivery
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| E-Mail |
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