| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
고분자_포스터 |
| 제목 |
Thermo-sensitive Injectable N-hexanoyl Glycol Chitosan Hydrogel for Percutaneous Treatment of Degenerative Disc Disease |
| 초록 |
Disc herniation is one of the most common intervertebrate disc (IVD) diseases. The use of injectable hydrogel formulations have been suggested as a promising strategy for the treatment of degenerative disc disease that can both restore the biomechanical function and reduce the low back pain. Here, a new thermo-sensitive injectable N-hexanoyl glycol chitosan (HGC) hydrogel was fabricated with tunable thermo-sensitivity and high stability. Various HGCs that show thermo-sensitive sol-gel transition properties were synthesized and their physicochemical properties were characterized by 1H NMR, FT-IR and rheological measurements. HGC hydrogel was injected into the degenerated IVD ex vivo model and evaluated by macroscopic observation, micro-computed tomography examination and histological analysis. The defected IVD was fully filled with HGC hydrogel, which was stable even at 28 days. These results suggested that HGC hydrogel has great potential for percutaneous treatment of disc herniation. |
| 저자 |
허강무1, 이정정1, 심혜은2, 강선웅2, 권보선3
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| 소속 |
1충남대, 2안전성평가(연), 3우리들휴브레인 |
| 키워드 |
Thermo-sensitive hydrogel; Injectable hydrogel; N-hexanoyl glycol chitosan; Disc herniation |
| E-Mail |
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